发明名称 |
Polymyxin derivative, combination product, pharmaceutical composition and uses thereof |
摘要 |
<p>The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms; and to a combination product comprising at least two such derivatives. The invention further relates to a method for sensitizing Gram-negative bacteria to an antibacterial agent by administering, simultaneously or sequentially in any order a therapeutically effective amount of said antibacterial agent and a derivative according to the present invention to said subject; to methods for developing novel antibiotics; and for sensitizing clinically important bacteria to a host defense mechanism complement present in serum. The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives.</p> |
申请公布号 |
IL207275(A) |
申请公布日期 |
2015.07.30 |
申请号 |
IL20100207275 |
申请日期 |
2010.07.29 |
申请人 |
NORTHERN ANTIBIOTICS OY;MARTTI VAARA;TIMO VAARA |
发明人 |
MARTTI VAARA;TIMO VAARA |
分类号 |
A61K;A61P;C07K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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