主权项 |
1. A compound of Formula I: wherein: R1 is —C(O)OC(R4)(R5)—OC(O)(G12)mR6; wherein each R4 and R5 is independently selected from hydrogen, C1-C3 alkyl, aryl or substituted aryl; preferably, hydrogen or methyl; G12 is selected from absent, NH, CH2, —S— or —O—; m is 0 or 1; R6 is selected from C13-C26-alkyl, substituted C13-C26-alkyl, C13-C26-alkenyl, substituted C13-C26-alkenyl, C13-C26-alkynyl, substituted C13-C26-alkynyl, C13-C26-cycloalkyl, and substituted C13-C26-cycloalkyl, aryl-C13-C26-alkyl, substituted aryl-C13-C26-alkyl, C1-C10-aryl, substituted C1-C10-aryl, heteroaryl-C13-C26-alkyl, substituted heteroaryl-C13-C26-alkyl; optionally substituted C13-C26-alkylaryl, optionally substituted C13-C26-alkenylaryl and optionally substituted C13-C26-alkynylaryl; R2 and R3, together with the nitrogen atom to which they are attached, form a secondary amine-containing parent drug, or a substituted secondary amine-containing parent drug. |