PARTICULATE DRUG DELIVERY METHODS

摘要

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

主权项

1. A compound that directly activates procaspase-3 upon contacting procaspase-3, wherein the compound is a novel compound of Formula I:wherein
R1 is an optionally substituted benzoyl; n is 1, 2, 3, or 4; and each R2 is independently H, alkyl, alkoxy, hydroxy, carboxy, halo, amino, alkylamino, dialkylamino, trifluoromethyl, trifluoromethoxy, benzyl, benzyloxy, nitro, cyano (—CN), sulfonamide (—SO2NH2), 2-propenyl, acetylene, N-alkyl-triazole, or N-benzyl-triazole; or two R2 groups form an ortho-fused benzo group; or a pharmaceutically acceptable salt or solvate thereof.