NEW PROCESS

摘要

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

主权项

1. A process for preparing a compound of formula (3), or a salt thereof,wherein X is halogen or —O—R5, wherein R5 is C1-C6-alkyl;
comprising reacting a compound of formula (4), wherein X is halogen or —O—R5, wherein R5 is C1-C6-alkyl; with a biphenylic compound, to obtain a compound of formula (3) or salt thereof.