ASSAY AND METHOD FOR THE IDENTIFICATION OF INDIVIDUAL RESPONSIVENESS TO IMMUNOGLOBULIN THERAPY

摘要

A method for determining the likelihood of response of an individual, suffering from a disease, towards immunoglobulin therapy has the steps of
providing a sample containing B- and T-lymphocytes, natural killer cells, invariant T-cells and monocytes of the individual;genotyping of at least one of the polynucleotides of an ADAMTS9-Intron; a KLHDC8A-Intron or of a flanking region of the CD14 gene, andawarding the value of 1 for the homozygous Single Nucleotide Polymorphism combinations, which suggests that the blood sample stems from a person which will not respond to immunoglobulin treatment,while awarding the value of 0 for SNP not meeting that criteria, which suggests that the blood sample stems from a person which will respond to immunoglobulin treatment.

主权项

1. A method for determining the likelihood of response of an individual, suffering from a disease, towards immunoglobulin therapy comprising the steps of
providing a sample containing B- and T-lymphocytes, natural killer cells, invariant T-cells and monocytes of the individual; genotyping of at least one of the polynucleotides of an ADAMTS9-Intron; a KLHDC8A-Intron or of a flanking region of the CD14 gene, and awarding the value of 1 for the homozygous Single Nucleotide Polymorphism combinations, which suggests that the blood sample stems from a person which will not respond to immunoglobulin treatment, while awarding the value of 0 for SNP not meeting that criteria, which suggests that the blood sample stems from a person which will respond to immunoglobulin treatment.