| 主权项 |
1. A method of providing therapy to a patient in need thereof, the method comprising
administering to a patient in need thereof a complex comprising a plurality of nanoparticles and/or quantum dots associated with at least one aptamer targeting the nanoparticles and/or quantum dots to a site, under conditions sufficient to permit accumulation of the complex at the target site, providing an energy source at the target site to penetrate the tissue and controllably heat the nanoparticles and/or quantum dots and generate thermal energy to induce a photoacoustic signal or sound wave from the nanoparticles and/or quantum dots, using a processor to control the amount of thermal energy delivered at the desired temperature to the target site, recording the temperature and photoacoustic signal or sound wave from the target site or from one or more multiple locations, and amplifying and processing the recorded photoacoustic signal or sound waves to generate a computational tomographic image of the nanoparticles and/or quantum dots at the target site. |
