发明名称 |
DDR2 MUTATIONS AS TARGETABLE FEATURES OF MELANOMA OR BASAL CELL CARCINOMA |
摘要 |
Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF. |
申请公布号 |
WO2014105966(A3) |
申请公布日期 |
2015.07.30 |
申请号 |
WO2013US77832 |
申请日期 |
2013.12.26 |
申请人 |
QUEST DIAGNOSTICS INVESTMENTS INCORPORATED |
发明人 |
JONES, DANIEL M.;WANG, YONGBAO;BILLOUIN-FRAZIER, SHERE;WINDHAM, JUSTIN |
分类号 |
G01N33/574;C12Q1/68 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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地址 |
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