| 发明名称 |
PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO |
| 摘要 |
The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein. |
| 申请公布号 |
US2015210648(A1) |
申请公布日期 |
2015.07.30 |
| 申请号 |
US201514679421 |
申请日期 |
2015.04.06 |
| 申请人 |
Arena Pharmaceuticals |
发明人 |
CARLOS Marlon;DONG Weitong;MACIAS Mark;SATO Suzanne Michiko;SELVEY Lee Alani |
| 分类号 |
C07D231/12 |
主分类号 |
C07D231/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparing Form I of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea comprising the step of:
converting an acetonitrile solvate of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea to provide said Form I of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea. |
| 地址 |
San Diego CA US |
