| 发明名称 |
A METHOD OF CRYSTALLIZATION OF (S)-N-METHYL-3-(1-NAPHTHYLOXY-3-(2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE) |
| 摘要 |
(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride of formula (I) is crystallized in such a way that suspension of duloxetine in a mixture of an aprotic solvent and a protic solvent is stirred at an increased temperature under simultaneous reduction of the volume proportion of the protic solvent. |
| 申请公布号 |
EA021528(B1) |
申请公布日期 |
2015.07.30 |
| 申请号 |
EA20120090127 |
申请日期 |
2010.09.02 |
| 申请人 |
ZENTIVA, K.S. |
发明人 |
RIDVAN LUDEK;CINIBULK JOSEF;GRUNWALDOVA VERONIKA;BRUSOVA HANA |
| 分类号 |
C07D333/16;C07D333/20 |
主分类号 |
C07D333/16 |
| 代理机构 |
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