<p>Abstract The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA 5 encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-l RAcP in order to increase the amount of a soluble IL-1RAcP.The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.</p>
VAN OMMEN, GARRIT-JAN BOUDEWIJN;AARTSMA-RUS, ANNEMIEKE;VAN DEUTEKOM, JUDITH CHRISTINA THEODORA;DE KIMPE, JOSEPHUS JOHANNES;VERBEEK, JOSEPH STEPHAN;YILMAZ-ELIS, ALIYE SEDA
