METHODS OF MODULATING UBIQUITIN LIGASE ACTIVITY

摘要

Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods reduce the level of oligomer formation such as homotrimeric E6AP ligase to reduce the enzyme activity. Alternatively, agents are provided that can promote the association of the ligase monomers, thereby increasing the ligase activity. Accordingly, novel therapeutic strategies are provided that are useful for the treatment of pathologies resulting from mutations in the genes encoding the ligases and which adversely increase or decrease a ubiquitination reaction.

主权项

1. A method of modulating the activity of a ubiquitin-protein E3 ligase comprising contacting a ubiquitin-protein E3 ligase with an agent that reduces ligase oligomer formation or with an agent that increases ligase oligomer formation.