PHARMACEUTICAL COMPOSITIONS FOR TOPICAL DELIVERY OF PHOTOSENSITIZERS AND USES THEREOF

摘要

The present disclosure includes and provides compositions comprising photosensitizing agents and their use in photodynamic therapy for the treatment of dermatological conditions.

主权项

1. A pharmaceutical composition useful for localizing a photosensitizer to a sebaceous gland, comprising a constituted formulation of a photosensitizing component comprising a photosensitizer supersaturated at ambient temperature, one or more solvents, and diethylene glycol monoethyl ether (DGME),
wherein the photosensitizer is lemuteporfin or verteporfin present at a final concentration (w/w) of between about 0.1% to about 0.4% in the pharmaceutical composition; and wherein the one or more solvents comprise benzyl alcohol present at a final concentration (w/w) of between about 5% and about 55% and isopropanol (IPA) at a final concentration (w/w) of between about 25% to about 60% in the pharmaceutical composition; wherein the DGME is present at a final concentration (w/w) of about 15% and about 35%; and wherein the constituted formulation was formed by combining:
a) a first solution of lemuteporfin or verteporfin present in an initial concentration (w/w) of between about 0.5% and 1.5% dissolved in benzyl alcohol; andb) a second solution of a diluent component comprising DGME present at an initial concentration (w/w) of between about 15% and about 40%, benzyl alcohol present at an initial concentration (w/w) of between about 0% and about 30%, and isopropanol (IPA) present at an initial concentration (w/w) of between about 30% and about 70% in the pharmaceutical composition; wherein the concentration of the photosensitizer in the constituted formulation is supersaturated at ambient temperature.