| 发明名称 |
USE OF ALKYLATED SEMI-SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS FOR THE TREATMENT OF INFLAMMATION |
| 摘要 |
Described herein are methods for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C1-C10 unsubstituted alkyl group or fluoroalkyl group. |
| 申请公布号 |
US2015209385(A1) |
申请公布日期 |
2015.07.30 |
| 申请号 |
US201514613523 |
申请日期 |
2015.02.04 |
| 申请人 |
University of Utah Research Foundation |
发明人 |
PRESTWICH GLENN;ZHANG Jianxing;KENNEDY Thomas P.;RAO Narayanam |
| 分类号 |
A61K31/728;A61K45/06 |
主分类号 |
A61K31/728 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said modified hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue substituted with a C1-C10 unsubstituted alkyl group or fluoroalkyl group. |
| 地址 |
Salt Lake City UT US |
