发明名称 |
NANO-IN-MICRO PARTICLES FOR INTRADERMAL DELIVERY |
摘要 |
The present invention relates to nano-in-micro particles for intradermal delivery of active substances. The nano-in-micro particles according to the invention comprise a matrix of microparticles and nanoparticles carrying at least one active substance and wherein the nanoparticles are dispersed in the matrix of microparticles. In a preferred embodiment of the invention the nano-in-micro particles comprise a densifier. In particular, the invention relates to nano-in-micro particles wherein the nanoparticles carry at least one vaccine and the use of the respective nano-in-micro particles for immunization. The invention further relates to the preparation of such nano-in-micro particles and the use thereof. In addition, the invention relates to compositions comprising these nano-in-micro particles, in particular pharmaceutical compositions. |
申请公布号 |
WO2015110656(A1) |
申请公布日期 |
2015.07.30 |
申请号 |
WO2015EP51604 |
申请日期 |
2015.01.27 |
申请人 |
LTS LOHMANN THERAPIE-SYSTEME AG |
发明人 |
WINTER, GERHARD;ENGERT, JULIA;DENG, YIBIN |
分类号 |
A61K38/00;A61K9/50;A61K9/51 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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