发明名称 |
OLIGONUCLEOTIDE AND ARTIFICIAL NUCLEOSIDE HAVING GUANIDINE BRIDGE |
摘要 |
An oligonucleotide or a pharmacologically acceptable salt thereof of the present invention contains a compound represented by formula I or II or a salt thereof, and at least one of nucleoside structures represented by formula I' or II' . According to the present invention, provided is a nucleic acid molecule for oligonucleotides having high binding affinity and specificity to a target nucleic acid, and exhibiting high nuclease resistance. |
申请公布号 |
EP2899197(A1) |
申请公布日期 |
2015.07.29 |
申请号 |
EP20130838365 |
申请日期 |
2013.09.19 |
申请人 |
OSAKA UNIVERSITY |
发明人 |
OBIKA, SATOSHI;KOTOBUKI, YUTARO;WAKI, REIKO |
分类号 |
C07H19/06;C07H19/16;C07H21/02;C12N15/00 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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