发明名称 |
MULTILAYER BIODEGRADABLE MICROPARTICLES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS |
摘要 |
Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the third composition. |
申请公布号 |
EP2897597(A2) |
申请公布日期 |
2015.07.29 |
申请号 |
EP20130839275 |
申请日期 |
2013.09.20 |
申请人 |
OHR PHARMA, LLC |
发明人 |
RHODES, CHRIS;MALAVIA, NIKITA;JENNINGS, ROBERT;LAXMA, REDDY;NORMAN, BETTY |
分类号 |
A61K9/58;A61K9/50;A61K31/433;A61K31/542 |
主分类号 |
A61K9/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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