发明名称 |
PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE |
摘要 |
<p>A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent (100) and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances (110) for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand (120) such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug- coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.</p> |
申请公布号 |
EP1753476(B1) |
申请公布日期 |
2015.07.29 |
申请号 |
EP20050747612 |
申请日期 |
2005.03.10 |
申请人 |
ORBUSNEICH MEDICAL, INC. |
发明人 |
COTTONE, ROBERT, JOHN, JR.;ROWLAND, STEPHEN, M.;DAVIS, HORACE, R.;KUTRYK, MICHAEL, J., B. |
分类号 |
A61L31/10;A61F2/00;A61F2/852;A61F2/86;A61L31/14;A61L31/16 |
主分类号 |
A61L31/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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