METHOD FOR PREPARATION OF ALUMINUM HYDROXYPHOSPHATE ADJUVANT
摘要
The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.
申请公布号
EP2782594(A4)
申请公布日期
2015.07.29
申请号
EP20120851733
申请日期
2012.11.19
申请人
MERCK SHARP & DOHME CORP.
发明人
THIRIOT, DAVID, S.;AHL, PATRICK, L.;CANNON, JAYME;LOBEL, GABRIEL, M.