发明名称 |
MONOCLONAL ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF |
摘要 |
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia. |
申请公布号 |
EP2260055(B1) |
申请公布日期 |
2015.07.29 |
申请号 |
EP20090715176 |
申请日期 |
2009.02.27 |
申请人 |
ABBVIE DEUTSCHLAND GMBH & CO KG;ABBVIE INC. |
发明人 |
MÜLLER, BERNHARD, K.;SCHMIDT, MARTIN;BARLOW, EVE, H.;LEDDY, MARY, R.;HSIEH, CHUNG-MING;BARDWELL, PHILLIP, D. |
分类号 |
C07K16/22;A61K39/00;A61K39/395 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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