TREATMENT OF ALZHEIMER'S AND COGNITIVE IMPAIRMENT WITH ANDROGRAPHOLIDES

摘要

We found that Andrographolide binds to GSK-3&bgr;: In so doing, andrographolide prevents changes in neuropathology in an Alzheimer's model, reducing Amyloid-&bgr; peptide levels, changing the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-&bgr;. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may be used to treat Alzheimer's disease.