Imatinib mesylate preparation procedure

摘要

The present invention concerns a procedure for the preparation of Imatinib mesylate having a content of residual solvents in compliance with ICH guidelines. In particular, the invention concerns a procedure for the preparation of Imatinib mesylate of formula (I):
comprising the treatment of a suspension of Imatinib mesylate in an organic solvent with a crusher/disperser comprising one or more stator combinations and one or more rotors.