Bridged element for detection of a target substance

摘要

A device comprising: a template molecule linked between at least two contact points including a first contact point disposed on a first surface and a second contact point disposed on a second surface, wherein the first surface is independent of the second surface, further wherein the template molecule includes at least one binding site for a target molecule; and a detector coupled to the first contact point, the first contact point having a first physical parameter, the detector configured to generate an output signal based on a change in the first physical parameter, wherein the change in the first physical parameter corresponds to an association of the target molecule and the template molecule.