发明名称 |
INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER |
摘要 |
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) &bgr;-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders. |
申请公布号 |
EP2897607(A2) |
申请公布日期 |
2015.07.29 |
申请号 |
EP20130838498 |
申请日期 |
2013.09.20 |
申请人 |
RHODE ISLAND HOSPITAL;MIDWESTERN UNIVERSITY |
发明人 |
WANDS, JACK, R.;DE LAMONTE, SUZANNE;AIHARA, ARIHIRO;OLSEN, MARK, JON;THOMAS, JOHN-MICHAEL |
分类号 |
A61K31/341;A61P35/00;C07D307/32;C07D307/66;C07D405/12;C07D409/04;C07D417/04 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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