Biodegradable and biocompatible shape memory polymers

摘要

This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments is linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.

主权项

1. A shape memory block copolymer comprising:
at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment comprising a poly(dimethylsiloxane) (PDMS); wherein the copolymer has a molecular weight, Mw, of about 50,000 g/mol to about 1,000,000 g/mol, wherein the switching segments and soft segments are randomly arranged in the copolymer, wherein at least one of the switching segments is linked to at least one of the soft segments by at least one linkage, wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus, and wherein the copolymer has a response time of less than 10 seconds, wherein the response time is the time for the copolymer to transform back to the first shape from the second shape after application of the second stimulus using a sample pre-stretched to 200% strain and having dimensions of 0.4 mm×3 mm×10 mm.