Composition

摘要

Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.

主权项

1. A solid pharmaceutical composition for oral administration comprising a substantially amorphous taxane, a hydrophilic carrier, and a surfactant, wherein the taxane is partly molecularly dispersed in the hydrophilic carrier, wherein the hydrophilic carrier is PVP-K30, wherein the surfactant is sodium dodecyl sulphate, wherein the taxane to hydrophilic carrier weight ratio is about 1:9 w/w, and wherein the weight ratio of surfactant to taxane is about 1:1 w/w.