| 发明名称 |
Monoclonal antibodies directed against the human immunodeficiency virus type 1 (hiv-1) P17 matrix (ma) protein |
| 摘要 |
Anti-HIV p17 monoclonal antibodies are described, which are capable of neutralizing the binding between multiple HIV-1 p17 protein variants and the p17R receptor are provided. Pharmaceutical compositions and methods of treatment utilizing these antibodies are also provided. |
| 申请公布号 |
US9090675(B2) |
申请公布日期 |
2015.07.28 |
| 申请号 |
US201113637997 |
申请日期 |
2011.03.30 |
| 申请人 |
Medestea Research & Production S.p.A. |
发明人 |
Caruso Arnaldo;Merizzi Giulia Federica;Soleti Antonio |
| 分类号 |
C07K16/10;A61K39/00 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
Alderson, Jr. Robert E. |
| 主权项 |
1. An isolated monoclonal antibody (mAb) that binds specifically to the human immunodeficiency virus type 1 (HIV-1) p17 matrix (MA) protein wherein said antibody comprises a heavy chain variable region (VH) encoded by the nucleic acid sequence of SEQ ID NO:10 and a light chain variable region (VL) encoded by the nucleic acid sequence of SEQ ID NO:11. |
| 地址 |
Colleretto Giacosa, TO IT |
