| 摘要 |
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts or prodrugs thereof, which inhibit the poly(ADP-ribose) polymerases (PARP) and therefore are useful for treating diseases, disorders, and conditions related to PARP. The present invention also discloses pharmaceutical compositions comprising a compound of formula (I), and methods of using such compounds to inhibit PARP enzymes, and to treat diseases, disorders, and conditions related to PARP.; |
| 主权项 |
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein:
A is CRa; wherein Ra is selected from the group consisting of hydrogen, halogen, and unsubstituted or substituted alkyl;L is selected from the group consisting of hydrogen, halogen, cynao, nitro, unsubstituted or substituted alkyl, and unsubstituted or substituted alkoxyl;Q1 and Q2 are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted heterocycloalkyl, unsubsituted or substituted aryl, and unsubstituted or substituted heteroaryl; or Q1 and Q2 together with the nitrogen atom to which they are attached may form cyclic moiety selected from the group consisting of unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heterocycicoalkenyl, and unsubstituted or substituted heteroaryl;each Y is independently selected from the group consisting of hydrogen, halogen, cyano, nitro, unsubstituted or substituted alkyl, OR1, and NR1R2;
wherein R1 and R2 are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, and unsubstituted or substituted heterocycloalkyl; andt=0, 1, or 2. |
