Chromatography column

摘要

A chromatography column comprises a tubular member (1) having an open inlet end and an outlet end and being adapted to receive a packing material, and an end piece (2) inserted through the inlet end of the tubular member (1). The end piece (2) comprises a generally planar inner end portion 4, and a rounded outer end portion (5), adapted to accommodate pressure forces acting on the inner end. The end piece (2) is fixed to the inner surface of the tubular member (1) by a weld- or bond-forming joining technique based on non-contact energy transfer, preferably laser welding. A method for manufacturing a pre-packed chromatography column is also disclosed.

主权项

1. A chromatography column, comprising:
a tubular member having an open inlet end and an outlet end and being adapted to receive a packing material; a first end piece capable of being inserted through the inlet end of the tubular member; wherein the end piece includes a first part having a generally flat base portion, a second part having a hollow generally dome-shaped portion having a ratio of dome height to dome bottom diameter of from about 20% to about 50%, and an intermediate structure including radial ribs extending between the first and second parts and configured to transmit pressure forces acting on the flat base portion to the dome-shaped portion to be accommodated thereby, wherein the first end piece is to be inserted with the generally flat base portion facing inwards towards an interior of the tubular member; and wherein the first end piece is adapted to be fixed to an inner surface of the tubular member by a joining technique based on non-contact energy transfer.