Compositions and methods for treatment of ear disorders

摘要

The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

主权项

1. A method of treating a subject suffering from or at risk of an ear disorder, comprising topically administering to the canal of the subject's ear an otic pharmaceutical composition comprising a therapeutically effective amount of at least one oligonucleotide compound, glycerol at a final concentration of about 0.1-30% v/v of the composition, and a pharmaceutically acceptable excipient or carrier, or mixtures thereof, thereby delivering said oligonucleotide compound to the inner ear and/or middle ear of a subject in an amount sufficient for down-regulating expression of a target gene associated with the disorder in the inner ear and/or middle ear of the subject.