Brain-derived neurotrophic factor or neurotrophin-4/5 to treat periodontal diseases and pulpal diseases

摘要

The objects of the present invention are: to provide a therapeutic agent and a therapeutic method for periodontal diseases and pulpal diseases, a transplant for periodontal tissue regeneration, and a method for regenerating the periodontal tissue.;According to the present invention, there are provided therapeutic agents for periodontal diseases and pulpal diseases which comprise neurotrophic factors as an active ingredient.

主权项

1. A method for treatment of periodontal disease which comprises administering a transplant comprising:
a therapeutically effective amount, per tooth or defect, of a neurotrophic factor for regenerating periodontal tissues, and a sheet or sponge impregnated with the neurotrophic factor, comprising a biodegradable protein material and a tissue absorbing material,to a subject who is suffering or prone to suffer from the disease in order to regenerate periodontal tissues, wherein the neurotrophic factor is a brain-derived neurotrophic factor or neurotrophin-4/5, wherein the therapeutically effective amount is in the range of 1×10−12 g to 1×10−3 g per tooth or defect, and wherein the biodegradable protein material is selected from the group consisting of collagen, gelatin, albumin, and platelet-rich plasma (PRP), and the tissue absorbing material is selected from the group consisting of hyaluronic acid (HA) and tricalcium phosphate (TCP).