| 主权项 |
1. A compound of formula (I) wherein A1 is —CH2— or —C(O)—; one of R1 and R2 is hydrogen and the other one is -A2-C(O)—R3; A2 is —NH— or absent; R3 is (A), (B) or (C); A3 is —CR18R19—, —NR20— or —C(O)—; A4 is nitrogen or —CR12—; R4 is hydrogen or alkoxycarbonyl; R5 is hydrogen or alkyl; R6 and R7 are independently selected from hydrogen and alkyl; R8 and R9 are independently selected from hydrogen and alkyl; R10, R11, R12 and R13 are independently selected from hydrogen, alkyl, nitro, fluoro, chloro, haloalkyl and alkoxy, provided that they are not all hydrogen at the same time; or R13 is alkoxycarbonyl and R10, R11 and R12 are all hydrogen at the same time; or R10, R11, R12 and R13 are all hydrogen at the same time, provided that:
at least two of R6, R7, R8 and R9 are alkyl and the other ones are hydrogen;or A1 is —C(O)—;or R1 is hydrogen and R2 is is -A2-C(O)—R3; R14 and R17 are independently selected from hydrogen and halogen; R15 and R16 are independently selected from hydrogen, morpholinyl and halogen; one of R18 and R19 is hydrogen and the other one is independently selected from alkylaminocarbonyl, hydroxyalkyl, alkyl, alkoxy and alkoxyalkoxy; or one of R18 and R19 is hydroxyalkyl and the other one is alkyl; or R18 and R19 are both hydrogen at the same time, provided that R4 is alkoxycarbonyl or R5 is alkyl; and R20 is alkyl; or a pharmaceutically acceptable salt thereof. |
