Estimating restitution curves in an anatomical mapping system

摘要

A method for mapping an anatomical structure includes sensing activation signals of physiological activity with a plurality of electrodes disposed in or near the anatomical structure, each activation signal having an associated cycle length, estimating an action potential duration and diastolic interval for each cycle length, generating a restitution curve based on the estimated action potential duration and diastolic interval from a preceding cycle length, iteratively optimizing each estimated action potential duration and corresponding diastolic interval to maximize a functional relationship between the estimated action potential duration and estimated diastolic interval from preceding cycle length, and generating an action potential duration restitution curve based on the optimized action potential durations and diastolic intervals.

主权项

1. A method for mapping an anatomical structure, the method comprising:
sensing activation signals of physiological activity with a plurality of electrodes disposed in or near the anatomical structure, each activation signal having an associated cycle length; estimating an action potential duration and diastolic interval for each cycle length; generating an initial restitution curve based on the estimated action potential duration and diastolic interval from a preceding cycle length; iteratively optimizing each estimated action potential duration and corresponding diastolic interval to maximize a functional relationship between the estimated action potential duration and estimated diastolic interval from preceding cycle length; and generating a final action potential duration restitution curve based on the optimized action potential durations and diastolic intervals.