Hepatic neuromodulation using microwave energy

摘要

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

主权项

1. A method of performing hepatic neuromodulation, the method comprising:
intravascularly positioning an ablation catheter within a portion of a common hepatic artery of a subject; delivering microwave energy, using the ablation catheter, to one or more sympathetic nerves within or surrounding a wall of the common hepatic artery, wherein the delivered energy is sufficient to ablate the one or more sympathetic nerves in a manner that facilitates a reduction in at least one of a blood glucose level or a lipoprotein level of the subject; and removing the ablation catheter from the subject.