发明名称 |
Reagent for diagnosing tumor, pharmaceutical composition, and screening method |
摘要 |
The present invention provides antibodies useful for diagnosing and treating tumors as well as methods of screening for antitumor agents. More specifically, tumors can be diagnosed and treated using an anti-phosphorylated p62 antibody that recognizes phosphorylation of serine at position 351 of an amino acid sequence of SEQ ID No. 1 or at a position corresponding thereto. An antitumor agent can be obtained by screening for a substance that inhibits the phosphorylation or that dephosphorylates the phosphorylated serine. |
申请公布号 |
US9090681(B2) |
申请公布日期 |
2015.07.28 |
申请号 |
US201313910544 |
申请日期 |
2013.06.05 |
申请人 |
Tokyo Metropolitan Institute of Medical Science |
发明人 |
Komatsu Masaaki;Ichimura Yoshinobu |
分类号 |
C07K16/18;C07K16/44;C07K14/47;C12Q1/48;G01N33/574;G01N33/68 |
主分类号 |
C07K16/18 |
代理机构 |
Barnes & Thornburg LLP |
代理人 |
Barnes & Thornburg LLP |
主权项 |
1. An anti-phosphorylated p62 antibody or an antigen-binding fragment thereof, wherein the antibody or the fragment thereof specifically binds to an epitope comprising a phosphorylated serine, the serine residing in the Keap1-interacting sequence of a p62 protein, and does not bind to a p62 protein that is not phosphorylated at said serine, wherein the Keap1-interacting sequence is STGE (SEQ ID NO:28). |
地址 |
Tokyo JP |