Phenyl-piperazine derivatives as serotonin reuptake inhibitors

摘要

The invention provides compounds represented by the general formula I;
wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

主权项

1. A process for the manufacture of a compound represented by formula Ia:wherein
s is 2; each R3 is independently selected from a group represented by halogen, cyano, nitro, C1-6-alkyl, or C1-6-alkyloxy;or an acid addition salt thereof, the process comprising reacting a compound of formula IVawith a compound of the formula Cl—CH2—CH2—NH—CH2—CH2—Cl or Br—CH2—CH2—NH—CH2—CH2—Br.