Method for regulating production of hemoglobin beta chains

摘要

A method is described for repressing production of β-globin protein and increasing production of γ-globin protein in a human cell utilizing a ferritin-H protein, a vector encoding ferritin-H, or an exogenous ferritin-H inducer.

主权项

1. A method for repressing production of β-globin protein and increasing production of γ-globin protein in a human cell, the method comprising the steps of:
providing at least one cell that is a precursor of or that is differentiating to become a human β-globin producing cell; providing a ferritin-H protein; and contacting the provided cell or cells with the ferritin-H protein, whereby the ferritin-H protein is introduced into the provided cell or cells; and culturing the provided cell or cells with the ferritin-H protein for a length of time sufficient so that the production of β-globin is decreased and the production of γ-globin is increased in the provided cell or cells.