Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions

摘要

The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below:;
in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

主权项

1. A method of reducing skin pigmentation, comprising applying to an area of human skin in need of reduced pigmentation a topical composition comprising an amount of a compound of formula (III) effective to reduce skin pigmentation, wherein Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH group (cis or trans) or CH2 group; n is a number, preferably an integer, ranging from 1 to 12; R2, R3, R6 and R7 are, independently of each other: a hydrogen atom; a hydroxyl group; a halogen atom; a salified or non-salified acid function; an aldehyde function; an amide function; a primary, secondary, or tertiary amine function in basic or salified form; a cyano group; a thiol group; a nitro group; a sugar; an O-heteroside; a linear or branched alkoxide group; a linear or branched alkyl chain; a linear or branched alkenyl chain; a linear or branched thioalkyl chain; a linear or branched alkoxy chain; an alkenyloxy chain; a salified or non-salified sulfate group; a salified or non-salified sulfonyl group; a salified or non-salified phosphonate group; a salified or non-salified phosphate group; or a silanol group in which one or more carbon-based chains may be substituted.