| 发明名称 | Method for treating <i>Helicobacter pylori </i>infections | ||
| 摘要 | The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ. ID. No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ. ID. No. 1, or(b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ. ID. No. 1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT. | ||
| 申请公布号 | US9090676(B2) | 申请公布日期 | 2015.07.28 |
| 申请号 | US200712446226 | 申请日期 | 2007.10.19 |
| 申请人 | IMEVAX GMBH | 发明人 | Gerhard Markus;Schmees Christian;Prinz Christian |
| 分类号 | C07K7/00;C07K11/00;C12Q1/00;A61K38/00;A61K39/00;C07K16/12;A61K39/02;C07K16/40;C12N9/10;C12Q1/48 | 主分类号 | C07K7/00 |
| 代理机构 | Rossi, Kimms & McDowell LLP | 代理人 | Rossi, Kimms & McDowell LLP |
| 主权项 | 1. An immunogenic composition comprising an inactivated form of gamma glutamyl transpeptidase of Helicobacter pylori (HPGGT) having an amino acid sequence according to SEQ ID NO: 1, wherein the serine residues at positions 451 and 452 are replaced by alanine residues. | ||
| 地址 | DE | ||