Multi-modal surface plasmon polariton—raman scattering based bio-detection

摘要

Methods and systems for combined SPP and Raman scattering-based bio-detection are provided. Embodiments include a bio-detection system having a microfluidics chip, a Surface Plasmon Polariton (SPP)-based system component, and a Raman scattering-based system component. The SPP-based and the Raman scattering-based system components can be used simultaneously or individually separately to detect biological and/or chemical analytes. The bio-detection system further includes an aerosol collector chip. Embodiments of the present invention can be used aboard means of propagation of biological and/or chemical analytes, including, for example, commercial aircrafts. Embodiments of the present invention can be used to enable an aircraft warning system.

主权项

1. A method for bio-detection using a microfluidics chip having a liquid-metal (LM) interface and a substrate-metal (SM) interface, comprising:
directing light at said microfluidics chip; measuring a first energy associated with photons of said light that interact with a first surface plasmon polariton (SPP) mode of said LM interface; measuring changes in said first energy; measuring a second energy associated with photons of said light that interact with a second SPP mode of said SM interface; measuring changes in said second energy; calibrating said changes in said first energy according to said changes in said second energy; and detecting, using said calibrated changes in said first energy, refractive index changes within said microfluidics chip, wherein said refractive index changes result from bio-receptor molecules within said microfluidics chip binding with analytes, wherein said microfluidics chip comprises a nanohole array.