Antibacterial coatings that inhibit biofilm formation on implants

摘要

Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with the surface. As shown in the examples below, clinical observations, digital radiography, and a battery of well-accepted ex vivo analytical methods show that the presence of a hydrophobic polycationic polymer coating, such as N,N-dodecyl,methyl-PEI coating on the surface of a metal implant, was effective in eliminating the clinical signs of infection in vivo in a large animal infection model. Moreover, the coated plates supported bone healing, and in fact decreased healing times, even in the presence of significant bacterial contamination compared to a control.

主权项

1. An implant comprising a polymeric coating on an outer surface of the implant, wherein the implant is selected from the group consisting of prosthetic implants, orthopedic implants, ear, nose, and throat implants, and cardiovascular implants, wherein the polymer forming the coating is an antimicrobial hydrophobic polycationic polymer selected from the group consisting of poly(4-vinyl-N-alkylpyridine), N,N-dialkylated branched polyethylene iminie, and N,N-dialkylated linear polyethylene imine polymers.