发明名称 |
Methods for preparing polymeric reagents |
摘要 |
The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety. |
申请公布号 |
US9090740(B2) |
申请公布日期 |
2015.07.28 |
申请号 |
US201414570705 |
申请日期 |
2014.12.15 |
申请人 |
Nektar Therapeutics |
发明人 |
Bentley Michael D.;Culbertson Sean M.;McManus Samuel P. |
分类号 |
A61K9/00;C08G65/338;C07D207/46;A61K31/765 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
Wilson Mark A. |
主权项 |
1. A polymeric reagent of the following formula: wherein (n) is an integer of from about 100 to about 2300. |
地址 |
San Francisco CA US |