Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative

摘要

A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.;;wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(═O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl,;
or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.

主权项

1. A method for treating osteoporosis in a mammal, comprising administering a compound selected from the group consisting of methyl 2-butyl-6-styryl-1-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-5-carboxylate; or methyl 2-butyl-5-styryl-1-[2′-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-benzimidazol-6-carboxylate, or a pharmaceutical acceptable salt thereof to the mammal in need thereof.