Alkyne substituted quinazoline compound and methods of use

摘要

The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).

主权项

1. A compound of the formula (I):or a salt thereof, wherein:
W is N; RA is a substituted aryl or substituted heteroaryl; each RB and RC is independently H, C1-C3 alkyl or C3-C6 cycloalkyl, where each of the C1-C3 alkyl and C3-C6 cycloalkyl of RB and RC is optionally substituted with 1 to 3 groups independently selected from the group consisting of oxo, halogen and —OR1; or RB and RC are taken together with the nitrogen atom to which they are attached to form a 4 to 7-membered heterocyclyl, which is optionally substituted with 1 to 3 groups independently selected from the group consisting of halogen, oxo, —OR1, —NR2R3, C1-C3 alkyl and C3-C6 cycloalkyl; RD is a heterocyclyl containing 1 to 3 hetero ring atoms independently selected from oxygen, nitrogen and sulfur, where the heterocyclyl of RD is optionally substituted with 1 to 3 groups independently selected from halogen, oxo, —OCF3, —OR1, —CF3, —NR2R3, C1-C3 alkyl and C3-C6 cycloalkyl; and each R1, R2 and R3 is independently selected from H and C1-C3 alkyl.