9-substituted minocycline compounds

摘要

The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

主权项

1. A compound of formula II:wherein:
R4′, R4″, R7′, and R7″ are each independently C1-C6 alkyl; and R9 is methyl, ethyl, n-propyl, i-propyl, or C1-C6 alkyl substituted with a substituent selected from the group consisting of hydroxyl, sulfonamide and cycloalkyl, or a pharmaceutically acceptable salt thereof.