| 主权项 |
1. A method of reducing cell proliferation in an individual having neoplasia, wherein the method consists essentially of administering to the individual synergistically effective combinations, with respect to one another, selected from the group consisting of:
i) a compound having the structure of Formula I; its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds together with a compound having the structure of Formula II; wherein R1 is hydrogen, C1-C6 alkyl; R2 is hydrogen, C1-C6 alkyl, or C2-C6 acyl; and R3-R10 are independently hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, or C2-C6 acyl, with the proviso that at least four of R3-R10 are hydrogen, its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds; ii) the compound having the structure of Formula I, its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds and a compound having the structure of Formula IV wherein R11-R13 are independently hydrogen or C1-C6 alkyl; and R14-R20 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, or C2-C6 acyl, with the proviso that at least three of R14-R20 are hydrogen, its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds; and iii) a compound of Formula II its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds and Formula IV, its pharmaceutically acceptable salts and esters, selectively substituted analogues, or a combination of one or more of the foregoing compounds, and wherein for the combinations ii) and iii) the neoplasia is a chemotherapy resistant neoplasia. |
