| 主权项 |
1. A compound of Formula I: wherein Q is a portion of a polymethine bridge having the formula: wherein Q is the central portion of a seven-polymethine-carbon polymethine bridge; each R1 is a member selected from the group consisting of -L-Y—Z and an alkyl that is additionally substituted with from 0 to 1 R14 and from 0 to 1 -L-Y—Z; wherein the alkyl is optionally interrupted by at least one heteroatom; each R2a and R2b is a member independently selected from the group consisting of alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, alkylthioalkyl, carboxyalkyl, alkoxycarbonylalkyl, or sulfonatoalkyl; wherein a carbon of the member is additionally substituted with from 0 to 1 -L-Y—Z; or, alternatively, an R2a and R2b pair, together with the ring carbon to which the R2a and R2b are bonded, join to form a spirocycloalkyl ring, wherein the spirocycloalkyl ring is additionally substituted with from 0 to 6 R14 and from 0 to 1 -L-Y—Z, or an exocyclic alkene, wherein the exocyclic alkene is additionally substituted with from 0 to 2 R14 and from 0 to 1 -L-Y—Z; each R3, R4, R5, and R6 is a member independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, hydroxyl, alkoxy, amino, cyano, carboxyl, alkoxycarbonyl, amido, sulfonato, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, and sulfonatoalkyl; wherein a carbon of the member is additionally substituted with from 0 to 1 R13 or from 0 to 1 -L-Y—Z; or, alternatively, a pair of said members that is selected from the group consisting of an R3 and R4, an R4 and R5, and an R5 and R6, together with the pair of atoms to which the pair of said members is bonded, joins to form an aryl ring, wherein the aryl ring is additionally substituted with from 0 to 2 R14 and from 0 to 1 -L-Y—Z; each R7 is a member independently selected from the group consisting of hydrogen and alkyl; wherein the alkyl is additionally substituted with from 0 to 3 R14 and from 0 to 1 -L-Y—Z; or, alternatively, both R7, together with the intervening segment of the polyene to which both R7 are bonded, join to form a ring, wherein said ring is selected from the group consisting of a cycloalkyl and a heterocyclyl ring; wherein the ring is additionally substituted with from 0 to 3 R14 and from 0 to 1 -L-Y—Z; R8, R9, R10, R11 and R12 are each a member independently selected from the group consisting of hydrogen, alkyl, alkenyl, halo, alkoxy, sulfonato, hydroxyl, amino, carboxyl, alkoxycarbonyl, cyano, amido, thioacetyl, and -L-Y—Z; wherein at least one member selected from the group consisting of R8, R9, and R10 is halo; each R13 is a member independently selected from the group consisting of hydroxyl, amino, carboxyl, and alkoxycarbonyl; each R14 is a member independently selected from the group consisting of alkyl, alkenyl, halo, hydroxyl, alkoxy, amino, amido, amidoalkyl, cyano, cyanoalkyl, carboxyl, alkoxycarbonyl, amido, sulfonato, sulfonatoalkyl, thioacetyl, thioacetylalkyl, alkoxycarbonylalkyl, and alkoxyalkyl; wherein the alkyl or alkenyl is additionally substituted with from 0 to 1 R13 and from 0 to 1 -L-Y—Z; each L is an optional member independently selected from the group consisting of a bond, a C1-C20 alkylene, and a C1-C20 alkenylene; wherein the alkylene or alkenylene is optionally interrupted by at least one heteroatom; each Y is an optional member independently selected from the group consisting of a bond, —O—, —S—, —NH—, —NHC(O)—, —C(O)NH—, —NR15—, —NR15C(O)—, —C(O)NR15—, —N(Z)—, —N(Z)C(O)—, and —C(O)N(Z)—; each Z is independently selected from the group consisting of -L-R13 and -L-R16; or alternatively, —Y—Z is a member selected from the group consisting of —N(Z)2, —N(Z)C(O)Z, and —C(O)N(Z)2, and the two Z groups may optionally be linked to form a cycloalkynyl group; each R15 is a member independently selected from the group consisting of alkyl and alkoxycarbonylalkyl; wherein the alkyl is optionally interrupted by at least one heteroatom; each R16 is independently a member selected from the group consisting of activated acyl, acrylamido, optionally substituted alkylsulfonate ester, azido, optionally substituted arylsulfonate ester, optionally substituted amino, aziridino, boronato, cycloalkynyl, cycloalkynylcarbonyl, diazo, formyl, glycidyl, halo, haloacetamidyl, haloalkyl, haloplatinato, halotriazino, hydrazinyl, imido ester, isocyanato, isothiocyanato, maleimidyl, mercapto, phosphoramidityl, a photoactivatable moiety, vinyl sulfonyl, alkynyl, cycloalkynyl, spirocycloalkynyl, a pegylated azido, a pegylated alkynyl, a pegylated cycloalkynyl, a pegylated spirocycloalkynyl, an o-diarylphosphino aryl ester, and an ortho substituted phosphine oxide aryl ester; and wherein said compound has a balanced charge. |
