Stable, non-irritating topical formulations of hydroquinone

摘要

Described herein are methods and compositions for increasing the efficacy and decreasing the irritancy of topical formulations of hydroquinone.

主权项

1. A method for increasing the efficacy of a hydroquinone-containing formulation, the formulation comprising an oil-in-water emulsion, comprising the step of adding a plurality of activating agents to the continuous phase of the formulation in an amount of about 8.5 to about 14.5% by weight of the formulation, thereby forming an improved hydroquinone containing formulation, wherein the activating agent is selected from the group consisting of niacinamide, alpha-arbutin, kojic acid, 1-methylhydantoine-2-imide, algae/mugwort extract, saccharomyces/xylinum/black tea ferment, palmaria palmate extract, brassica napus extract, hexapeptide-2, glycrrhiza glabra root extract, and combinations thereof.