Hybrid nanocrystals for treatment and bioimaging of disease

摘要

Hybrid nanocrystals able to reach specific targets in the body for treatment and biological imaging are provided, as well as methods of making and administering same for treatment of disease conditions and for bioimaging and radiotherapy. The hybrid nanocrystals and methods can be used alone or in combination with other treatment and imaging modalities.

主权项

1. A hybrid nanocrystal, comprising a drug providing a crystal lattice, and a ligand, wherein the ligand is integrated throughout the nanocrystal as a structural defect, and wherein the ligand induces receptor-mediated endocytosis when released from the hybrid nanocrystal or presented on the crystal surface.