| 发明名称 | Antibody formulations and methods | ||
| 摘要 | Antibody formulations and methods useful for prophylaxis or treatment of amyloidosis, including AA amyloidosis and AL amyloidosis. | ||
| 申请公布号 | US9089529(B2) | 申请公布日期 | 2015.07.28 |
| 申请号 | US201213660957 | 申请日期 | 2012.10.25 |
| 申请人 | Prothena Therapeutics Limited | 发明人 | Garidel Patrick;Henderson Isaac Craig;Klein Pamela |
| 分类号 | A61K9/19;A61K39/395;A61K47/26;A61K47/00;A61K31/195;C07K16/18;A61K31/198;A61K31/454;A61K31/69;A61K38/07 | 主分类号 | A61K9/19 |
| 代理机构 | Womble Carlyle Sandridge & Rice, LLP | 代理人 | Womble Carlyle Sandridge & Rice, LLP |
| 主权项 | 1. A lyophilized formulation of an antibody, comprising about: (a) 100 mg of a humanized version of antibody 2A4 (ATCC Accession Number PTA-9662) or antibody 7D8 (ATCC Accession Number PTA-9468) or antigen binding fragment thereof; (b) 27.2 mg L-histidine; (c) 15.7 mg L-histidine HCl monohydrate; (d) 870.2 mg of trehalose; and (e) 2.0 mg polysorbate 20. | ||
| 地址 | Dublin IE | ||