Method of reducing total cholesterol level by administering matrilin-2 polypeptide

摘要

The present invention provides, in part, methods and compositions for treating lipid disorders comprising administering a polypeptide that inhibits PCSK9. A novel method for identifying polypeptides that interact with PCSK9 is also provided.

主权项

1. A method for reducing total cholesterol level, low density lipoprotein cholesterol level, apolipoprotein B level, total cholesterol/high density lipoprotein ratio or low density lipoprotein/high density lipoprotein ratio, comprising administering to a patient with a disorder of cholesterol or lipid homeostasis, a therapeutically effective amount of a composition comprising matrilin-2 polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 1, amino acids 24-956 of SEQ ID NO: 2 and SEQ ID NO: 2.